KLF17 Expression in Colorectal Carcinoma and Its Clinical Significance / 中国医学科学院学报
Acta Academiae Medicinae Sinicae
;
(6): 69-72, 2016.
Article
in English
| WPRIM
| ID: wpr-289904
ABSTRACT
<p><b>OBJECTIVE</b>To detect KLF17 expression in colorectal carcinoma (CRC) and to evaluate its effect on the prognosis of colorectal carcinoma.</p><p><b>METHODS</b>Immunohistochemistry was performed to detect the expression of KLF17 in CRC and matched pericarcinous tissue,and the relationship between KLF17 expression and disease-free survival (DFS) was analyzed.</p><p><b>RESULTS</b>Of 73 CRC patients, KLF17 expression was positive in 32 patients and negative in 41 patients. KLF17 expression rate was significantly lower in CRC tissue than in pericarcinous tissue (χ(2)=12.418, P=0.001). The DFS of KLF17-positive stage III colon cancer patients was (56.3±7.2) months (95% CI 42-70 months), which was significantly longer than that [(32.3±5.5) months (95% CI 22-43 months)] of KLF17-negative patients (P=0.039).</p><p><b>CONCLUSION</b>KLF17 expression decreases in CRC tissue, and a positivie KLF17 expression predicts a better prognosis in stage III CRC patients.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Prognosis
/
Transcription Factors
/
Immunohistochemistry
/
Colorectal Neoplasms
/
Disease-Free Survival
Type of study:
Prognostic study
Limits:
Humans
Language:
English
Journal:
Acta Academiae Medicinae Sinicae
Year:
2016
Type:
Article
Similar
MEDLINE
...
LILACS
LIS