Correlation between Expression of Signal Transducer and Activator of Transcription 3 and Pituitary Adenoma Subtypes / 中国医学科学院学报
Acta Academiae Medicinae Sinicae
;
(6): 693-697, 2015.
Article
in Chinese
| WPRIM
| ID: wpr-289925
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the correlation between signal transducer and activator of transcription 3 (STAT3) expression and pituitary adenoma subtypes.</p><p><b>METHOD</b>The STAT3 expression profiles in different pituitary adenomas from 74 patients were determined using quantificational real-time polymerase chain reaction,Western blot,and immunohistochemistry.</p><p><b>RESULTS</b>Expression of STAT3 was observed in all pituitary adenoma subtypes. The STAT3 expression level was highest in growth hormone adenoma when compared with other tumors including prolactin,follicle-stimulating hormone/luteinizing hormone-secreting adenoma,and adrenocorticotrophic hormone-secreting adenoma. The follicle-stimulating hormone/luteinizing hormone adenomas exhibited the lowest STAT3 expression levels.</p><p><b>CONCLUSION</b>STAT3 is differentially expressed in pituitary adenoma subtypes, suggesting the cell-specific features of STAT3 regulation,although further investigations are still warranted to clarify the underlying mechanisms.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pituitary Neoplasms
/
Immunohistochemistry
/
Signal Transduction
/
Adenoma
/
Human Growth Hormone
/
STAT3 Transcription Factor
/
Real-Time Polymerase Chain Reaction
/
Follicle Stimulating Hormone
Limits:
Humans
Language:
Chinese
Journal:
Acta Academiae Medicinae Sinicae
Year:
2015
Type:
Article
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