Research Advances in NLRP3 Inflammasome-related Regulatory Mechanisms / 中国医学科学院学报
Acta Academiae Medicinae Sinicae
;
(6): 618-622, 2015.
Article
in Chinese
| WPRIM
| ID: wpr-289935
ABSTRACT
Inflammasome is one of the pattern recognition receptors whose activation directly relates to the maturity and secretion of proinflammatory cytokines interleukin (IL)-1Β and IL-18. Thus, it plays an important role in the humoral immunity. A growing number of studies have found that inflammasome has a close relationship with the pathogenesis of various diseases including atherosclerosis,diabetes, and gout. However,the activation of the inflammasome and its specific regulatory mechanisms remain not clear. This article reviews the possible regulatory mechanisms of the inflammasome NLRP3 in terms of oxidative stress, endoplasmic reticulum stress,and autophagy reaction.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Carrier Proteins
/
Interleukin-1beta
/
Inflammasomes
/
NLR Family, Pyrin Domain-Containing 3 Protein
/
Inflammation
Limits:
Animals
/
Humans
Language:
Chinese
Journal:
Acta Academiae Medicinae Sinicae
Year:
2015
Type:
Article
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