Effect of metoprolol on the expression of GRK2 in lymphocyte of advanced elderly patients with chronic heart failure / 南方医科大学学报
Journal of Southern Medical University
; (12): 1132-1133, 2010.
Article
in Zh
| WPRIM
| ID: wpr-289975
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the effect of metoprolol on the expression of G protein-coupled receptor kinases 2 (GRK2) in lymphocyte of advanced elderly patients with chronic heart failure.</p><p><b>METHODS</b>32 elderly patients with chronic heart failure were divided into control group and metoprolol group, 16 each. Conventional therapy was used in the control group, conventional therapy plua metoprolol was used in metoprolol group. The treatment courses were 8 weeks in both groups.</p><p><b>RESULTS</b>Left ventricular end-diastolic diameter and left ventricular ejection fraction were not different between the two groups. Lymphocyte GRK2 mRNA level in metoprolol group was lower than that in control group.</p><p><b>CONCLUSION</b>Metoprolol can inhibit the expression of GRK2 in lymphocyte of advanced elderly patients with chronic heart failure.</p>
Full text:
1
Index:
WPRIM
Main subject:
Pharmacology
/
Blood
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Lymphocytes
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Chronic Disease
/
G-Protein-Coupled Receptor Kinase 2
/
Genetics
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Heart Failure
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Metabolism
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Metoprolol
Limits:
Aged
/
Aged80
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Humans
Language:
Zh
Journal:
Journal of Southern Medical University
Year:
2010
Type:
Article