Dose-effect relationship of irbsartan with the changes in the renal tissue structure in diabetic rats / 南方医科大学学报
Journal of Southern Medical University
;
(12): 1066-1068, 2010.
Article
in Chinese
| WPRIM
| ID: wpr-289992
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the relationship between the dosage of irbesartan and the renal tissue structure in diabetic rats.</p><p><b>METHODS</b>Male Wistar rats was given a single intraperitoneal dose (mg/kg) of streptozotocin to induce diabetes. The diabetic rats were randomized into 4 groups and received 4 weeks later 25 mg/kg (n=9), 50 mg/kg (n=9), 200 mg/kg (n=9) irbesartan intragastrically, or equal volume of water (model group, n=11) on a daily basis. Seven normal rats receiving with equal volume of water served as the normal control. All the rats were sacrificed after 8 weeks and the 24-hour albumin excretion, renal mass index and the volume of the glomerulus were measured.</p><p><b>RESULTS</b>The 24-hour albumin excretion, renal mass index and volume of the glomerulus in the 3 irbesartan groups were significantly decreased as compare with those in the model group; the reductions in 50 and 200 mg/kg irbesartan groups were significant greater than those in 25 mg/kg irbesartan group.</p><p><b>CONCLUSION</b>Irbesartan can decrease the 24-hour urinary albumin excretion and relive glomerulopathy in diabetic rats. Within a certain dose range, irbesartan produces a dose-dependent protective effect on the renal structures in the diabetic rats.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Pharmacology
/
Tetrazoles
/
Biphenyl Compounds
/
Rats, Wistar
/
Diabetes Mellitus, Experimental
/
Dose-Response Relationship, Drug
/
Kidney
Limits:
Animals
Language:
Chinese
Journal:
Journal of Southern Medical University
Year:
2010
Type:
Article
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