Protective effect of polydatin on a PC12 cell model of oxygen-glucose deprivation / 南方医科大学学报

ABSTRACT

<p><b>OBJECTIVE</b>To evaluate the protective effect of polydatin on a PC12 cell model of oxygen and glucose deprivation (OGD).</p><p><b>METHODS</b>A pheochromocytoma cell injury model was induced by OGD to simulate the cerebral ischemic changes. The protective effects of polydatin were investigated in this model.</p><p><b>RESULTS</b>Polydatin treatment significantly enhanced the cell viability and reduced the levels of lactate dehydrogenase, nitric oxide and the malondialdehyde of the pheochromocytoma cells as compared with the OGD group. Polydatin also increased the activity of superoxide dismutase in the cells.</p><p><b>CONCLUSION</b>Polydatin offers protective effect against OGD-induced injury in pheochromocytoma cells.</p>