Correlation of adiponectin, monocyte chemoattractant protein-1, and endothelial function to vascular remodeling in coronary in-stent restenosis / 南方医科大学学报
Journal of Southern Medical University
;
(12): 912-914, 2010.
Article
in Chinese
| WPRIM
| ID: wpr-290029
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the correlation between vascular remodeling index (RI) and serum adiponectin, plasma monocyte chemoattractant protein-1 (MCP-1), endothelial function and evaluate the mechanism of coronary in-stent restenosis.</p><p><b>METHODS</b>RI 6 months after percutaneous coronary intervention (PCI), serum adiponectin, plasma MCP-1 and flow-mediated dilation (FMD) before and 3 days,6 months after PCI were measured in 30 patients with and 30 without coronary in-stent restenosis.</p><p><b>RESULTS</b>Compared with patients without restenosis and those with restenosis before PCI, the patients with coronary in-stent restenosis showed significantly increased plasma MCP-1 3 days and 6 months after PCI (P<0.05) and reduced RI 6 months after PCI, serum adiponectin and FMD 3 days and 6 months after PCI (P<0.05). RI was positively correlated to serum adiponectin and FMD and inversely to MCP-1.</p><p><b>CONCLUSION</b>The occurrence of coronary in-stent restenosis is the result of the interrelations between multiple factors.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Therapeutics
/
Blood
/
Endothelium, Vascular
/
Angioplasty, Balloon, Coronary
/
Stents
/
Chemokine CCL2
/
Coronary Disease
/
Coronary Restenosis
/
Adiponectin
Limits:
Adult
/
Aged
/
Female
/
Humans
/
Male
Language:
Chinese
Journal:
Journal of Southern Medical University
Year:
2010
Type:
Article
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