Effects of the blood glucose-adjusting recipe on blood glucose and pancreas islet pathology in diabetic mice / 南方医科大学学报

ABSTRACT

<p><b>OBJECTIVE</b>To study the effects of a self-formulated blood glucose-adjusting recipe on blood glucose and pathology of the pancreas in diabetic mice.</p><p><b>METHODS</b>Diabetes mellitus (DM) was induced in mice by injection of alloxan through the caudal vein. The blood glucose-adjusting recipe was administered in the mice at the doses of 20, 10 and 5 g/kg for 21 days, after which blood glucose was determined and the sugar tolerance was evaluated, and the pancreas and islet pathologies were examined microscopically.</p><p><b>RESULTS</b>The blood glucose-adjusting recipe at 20 g/kg significantly lowered the fast blood glucose in the mice, and at 20 and 10 g/kg, the recipe significantly lowered the blood glucose 2 h after glucose administration and increased the sugar tolerance. The pathological damage in the diabetic mice was alleviated after treatment with the recipe.</p><p><b>CONCLUSIONS</b>The blood glucose-adjusting recipe has a good effect in stabilizing blood glucose in mice.</p>