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Association Analysis of Proteasome Subunits and Transporter Associated with Antigen Processing on Chinese Patients with Parkinson's Disease / 中华医学杂志(英文版)
Chinese Medical Journal ; (24): 1053-1058, 2016.
Article in English | WPRIM | ID: wpr-290126
ABSTRACT
<p><b>BACKGROUND</b>Proteasome subunits (PSMB) and transporter associated with antigen processing (TAP) loci are located in the human leukocyte antigen (HLA) Class II region play important roles in immune response and protein degradation in neurodegenerative diseases. This study aimed to explore the association between single nucleotide polymorphisms (SNPs) of PSMB and TAP and Parkinson's disease (PD).</p><p><b>METHODS</b>A case-control study was conducted by genotyping SNPs in PSMB8, PSMB9, TAP1, and TAP2 genes in the Chinese population. Subjects included 542 sporadic patients with PD and 674 healthy controls. Nine identified SNPs in PSMB8, PSMB9, TAP1, and TAP2 were genotyped through SNaPshot testing.</p><p><b>RESULTS</b>The stratified analysis of rs17587 was specially performed on gender. Data revealed that female patients carry a higher frequency of rs17587-G/G versus (A/A + G/A) compared with controls. But there was no significant difference with respect to the genotypic frequencies of the SNPs in PSMB8, TAP1, and TAP2 loci in PD patients.</p><p><b>CONCLUSION</b>Chinese females carrying the rs17587-G/G genotype in PSMB9 may increase a higher risk for PD, but no linkage was found between other SNPs in HLA Class II region and PD.</p>
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Full text: Available Index: WPRIM (Western Pacific) Main subject: Parkinson Disease / Cysteine Endopeptidases / Case-Control Studies / Antigen Presentation / Polymorphism, Single Nucleotide / Proteasome Endopeptidase Complex / Allergy and Immunology / ATP Binding Cassette Transporter, Subfamily B, Member 2 / ATP Binding Cassette Transporter, Subfamily B, Member 3 / Genetics Type of study: Observational study / Prognostic study / Risk factors Limits: Adult / Aged / Female / Humans / Male Language: English Journal: Chinese Medical Journal Year: 2016 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Parkinson Disease / Cysteine Endopeptidases / Case-Control Studies / Antigen Presentation / Polymorphism, Single Nucleotide / Proteasome Endopeptidase Complex / Allergy and Immunology / ATP Binding Cassette Transporter, Subfamily B, Member 2 / ATP Binding Cassette Transporter, Subfamily B, Member 3 / Genetics Type of study: Observational study / Prognostic study / Risk factors Limits: Adult / Aged / Female / Humans / Male Language: English Journal: Chinese Medical Journal Year: 2016 Type: Article