Spontaneous emergence of overgrown molar teeth in a colony of Prairie voles (Microtus ochrogaster) / 国际口腔科学杂志·英文版
International Journal of Oral Science
;
(4): 23-26, 2015.
Article
in English
| WPRIM
| ID: wpr-290166
ABSTRACT
Continuously growing incisors are common to all rodents, which include the Microtus genus of voles. However, unlike many rodents, voles also possess continuously growing molars. Here, we report spontaneous molar defects in a population of Prairie voles (Microtus ochrogaster). We identified bilateral protuberances on the ventral surface of the mandible in several voles in our colony. In some cases, the protuberances broke through the cortical bone. The mandibular molars became exposed and infected, and the maxillary molars entered the cranial vault. Visualisation upon soft tissue removal and microcomputed tomography (microCT) analyses confirmed that the protuberances were caused by the overgrowth of the apical ends of the molar teeth. We speculate that the unrestricted growth of the molars was due to the misregulation of the molar dental stem cell niche. Further study of this molar phenotype may yield additional insight into stem cell regulation and the evolution and development of continuously growing teeth.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pedigree
/
Diagnostic Imaging
/
Arvicolinae
/
X-Ray Microtomography
/
Genetics
/
Molar
Type of study:
Diagnostic study
Limits:
Animals
/
Female
/
Humans
/
Male
Language:
English
Journal:
International Journal of Oral Science
Year:
2015
Type:
Article
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