CD20 Positive T Cell Lymphoma Involvement of Skin
Annals of Dermatology
;
: 529-535, 2011.
Article
in English
| WPRIM
| ID: wpr-29023
ABSTRACT
CD20 positive T cell lymphoma is a rare condition that is associated with the coexpressions of CD20 and T cell markers, such as, CD3, CD5, or UCHL-1. Positivity for CD20 in this tumor represents an aberrant immunophenotype, but the presence of monoclonal T cell receptor (TCR) gene rearrangements and negativity for immunoglobulin heavy chain gene rearrangement indicate that this tumor is a T cell lymphoma. The majority of cases of CD20 positive T cell lymphoma have been reported as immature peripheral T cell lymphoma not otherwise specified. However, we believe that this disease is likely to be re-listed as a new disease entity after its pathogenesis has been elucidated and more cases have been evaluated. Here, we present a case of peripheral T cell lymphoma coexpressing CD20 and T cell markers with a demonstrable TCR gene rearrangement, in a patient who had been misdiagnosed as having B cell type lymphoma 4 years previously. We hypothesize that in this case initially circulating normal CD20+ T cell subsets underwent neoplastic transformation and CD20 positive T cell lymphoma subsequently developed in the lymph node, and then recurred in the skin due to systemic disease or metastasized from the nodal disease.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Skin
/
Receptors, Antigen, T-Cell
/
Gene Rearrangement
/
T-Lymphocyte Subsets
/
Lymphoma, T-Cell
/
Lymphoma, T-Cell, Peripheral
/
Immunoglobulin Heavy Chains
/
Genes, T-Cell Receptor
/
Lymph Nodes
/
Lymphoma
Limits:
Humans
Language:
English
Journal:
Annals of Dermatology
Year:
2011
Type:
Article
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