Relationship between quinone oxidoreductase1 gene ns-cSNP and genetic susceptibility of esophageal cancer / 中华预防医学杂志
Chinese Journal of Preventive Medicine
;
(12): 324-327, 2006.
Article
in Chinese
| WPRIM
| ID: wpr-290266
ABSTRACT
<p><b>OBJECTIVE</b>To explore the relationship between quinone oxidoreductase1 (NQO1) gene nonsynonymous cSNP and the genetic susceptibility of esophageal cancer.</p><p><b>METHODS</b>Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) and Allele-Specific PCR (AS-PCR) were employed to assess the polymorphism of NQO1 genes both in 106 patients with esophageal cancer and control subjects matched by age, gender and origin.</p><p><b>RESULTS</b>It was shown that no C/C genotype was found at 406 of NQO1. The allelic frequency of NQO1 609T was significantly higher in patients with esophageal cancer than in the control subjects (P < 0.005) and the individuals with 609T allelic genotype of NQO1 gene were at greater risk to develop esophageal cancer (OR = 4.76, 95% CI = 1.064 - 3.397). But Individuals with mutant allele of NQO1 465 genotype did not show the rising risk of esophageal cancer.</p><p><b>CONCLUSIONS</b>The NQO1 C609T polymorphisms should likely be associated with the genetic susceptibility of esophageal cancer.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Esophageal Neoplasms
/
China
/
NAD(P)H Dehydrogenase (Quinone)
/
Genetic Predisposition to Disease
/
Polymorphism, Single Nucleotide
/
Alleles
/
Ethnology
/
Gene Frequency
/
Genetics
/
Genotype
Limits:
Humans
Country/Region as subject:
Asia
Language:
Chinese
Journal:
Chinese Journal of Preventive Medicine
Year:
2006
Type:
Article
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