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Seroepidemiology of dengue virus infection among adults in Singapore
Annals of the Academy of Medicine, Singapore ; : 667-675, 2009.
Article in English | WPRIM | ID: wpr-290335
ABSTRACT
<p><b>INTRODUCTION</b>To determine the seroepidemiology of dengue virus infection in a representative sample of the adult resident population aged 18 years old to 74 years old in Singapore and to estimate the proportion of asymptomatic dengue infection during the 2004 epidemic.</p><p><b>MATERIALS AND METHODS</b>The study was based on 4152 stored blood samples collected between September and December 2004 from participants aged 18 years old to 74 years old during the 2004 National Health Survey. Sera were tested for IgG and IgM antibodies using a commercial test kit (PanBio Capture/Indirect ELISA).</p><p><b>RESULTS</b>Of the study population, 59.0% and 2.6% tested positive for dengue IgG (past infection) and IgM/high-titre IgG (recent infection), respectively. Only 17.2% of young adults aged 18 years old to 24 years old were dengue IgG positive. Multivariate analyses showed that older age, Indian ethnicity and male gender were significantly associated with past infection, whereas only age was significantly associated with recent dengue infection. Based on the dengue cases notified during the period of survey, it was estimated that for every 23 individuals recently infected with dengue, only 1 was reported to the health authority as a clinical case.</p><p><b>CONCLUSION</b>The Singapore population is highly susceptible to dengue epidemics despite its aggressive Aedes prevention and control programme. The finding of a high proportion of unreported cases due to asymptomatic and subclinical infection poses a challenge for dengue control.</p>
Subject(s)
Full text: Available Index: WPRIM (Western Pacific) Main subject: Singapore / Immunoglobulin G / Immunoglobulin M / Confidence Intervals / Logistic Models / Odds Ratio / Seroepidemiologic Studies / Mosquito Control / Population Surveillance / Epidemiology Type of study: Etiology study / Observational study / Prevalence study / Prognostic study / Risk factors / Screening study Limits: Animals / Female / Humans / Male Country/Region as subject: Asia Language: English Journal: Annals of the Academy of Medicine, Singapore Year: 2009 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Singapore / Immunoglobulin G / Immunoglobulin M / Confidence Intervals / Logistic Models / Odds Ratio / Seroepidemiologic Studies / Mosquito Control / Population Surveillance / Epidemiology Type of study: Etiology study / Observational study / Prevalence study / Prognostic study / Risk factors / Screening study Limits: Animals / Female / Humans / Male Country/Region as subject: Asia Language: English Journal: Annals of the Academy of Medicine, Singapore Year: 2009 Type: Article