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The effect of nitric oxide/endothelins system on the hepatic ischemia/reperfusion injury / 华中科技大学学报(医学)(英德文版)
Journal of Huazhong University of Science and Technology (Medical Sciences) ; (6): 216-227, 2002.
Article in English | WPRIM | ID: wpr-290555
ABSTRACT
The relationship between the hepatic ischemia/reperfusion (I/R) injury and the balance of nitric oxide/endothelins (NO/ET) was studied. The changes of the ratio of NO/ET and the hepatic injury were observed in a rat hepatic I/R model pretreated with several tool drugs. In the acute phase of hepatic I/R injury, the ratio of plasma NO/ET was reduced from 1.58 +/- 0.20 to 0.29 +/- 0.05 (P < 0.01) and the hepatic damage deteriorated. NO donor L-Arg and ET receptor antagonist TAK-044 could alleviate the hepatic I/R injury to some degree, whereas NO synthase inhibitor L-NAME aggravated the damage. It was concluded that the hepatic I/R injury might be related with the disturbance of the NO/ET balance. Regulation of this balance might have an effect on the I/R injury.
Subject(s)
Full text: Available Index: WPRIM (Western Pacific) Main subject: Arginine / Blood / Reperfusion Injury / Endothelins / NG-Nitroarginine Methyl Ester / Endothelin Receptor Antagonists / Liver / Nitric Oxide Type of study: Prognostic study Limits: Animals Language: English Journal: Journal of Huazhong University of Science and Technology (Medical Sciences) Year: 2002 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Arginine / Blood / Reperfusion Injury / Endothelins / NG-Nitroarginine Methyl Ester / Endothelin Receptor Antagonists / Liver / Nitric Oxide Type of study: Prognostic study Limits: Animals Language: English Journal: Journal of Huazhong University of Science and Technology (Medical Sciences) Year: 2002 Type: Article