Mutation analysis of IgVH gene in B-cell chronic lymphocytic leukemia / 华中科技大学学报(医学)(英德文版)
Journal of Huazhong University of Science and Technology (Medical Sciences)
;
(6): 177-182, 2002.
Article
in English
| WPRIM
| ID: wpr-290566
ABSTRACT
The variable heavy chain region (VH) genes of 3 untreated patients with B-cell chronic lymphocytic leukemia (B-CLL) were cloned and analyzed. The VH family used was VH3-11, VH3-72 and VH3-33. More than 2% difference from the corresponding germline gene was detected in all the 3 obtained potential functional genes (average 16.7). Mutation pattern analysis indicated evidence of antigen selective pressure observed in 1 of 3 cases. Our findings suggested that the tumor cells originate from post-GC cells.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Immunoglobulin Variable Region
/
Molecular Sequence Data
/
Gene Rearrangement
/
Leukemia, Lymphocytic, Chronic, B-Cell
/
Amino Acid Sequence
/
Genetics
/
Mutation
Limits:
Humans
Language:
English
Journal:
Journal of Huazhong University of Science and Technology (Medical Sciences)
Year:
2002
Type:
Article
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