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Resistance and treatment strategy of gastrointestinal stromal tumor target therapy / 中华胃肠外科杂志
Chinese Journal of Gastrointestinal Surgery ; (12): 309-312, 2012.
Article in Chinese | WPRIM | ID: wpr-290798
ABSTRACT
Gastrointestinal stromal tumor(GIST) originates from interstitial cells of Cajal(ICCs). Tyrosine kinase inhibitors(TKI) such as imatinib and sunitinib, are effective agents besides surgery. However some GIST can become primarily or secondarily resistant to those drugs. The difference in gene mutation types and secondary gene mutation is the main cause. When the GIST is proved to be drug resistance, reasonable personal treatment strategies based on individualized medicine should be made to improve outcomes and quality of life.
Subject(s)
Full text: Available Index: WPRIM (Western Pacific) Main subject: Piperazines / Pyrimidines / Pyrroles / Benzamides / Drug Resistance, Neoplasm / Therapeutic Uses / Gastrointestinal Stromal Tumors / Protein Kinase Inhibitors / Drug Therapy / Imatinib Mesylate Limits: Humans Language: Chinese Journal: Chinese Journal of Gastrointestinal Surgery Year: 2012 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Piperazines / Pyrimidines / Pyrroles / Benzamides / Drug Resistance, Neoplasm / Therapeutic Uses / Gastrointestinal Stromal Tumors / Protein Kinase Inhibitors / Drug Therapy / Imatinib Mesylate Limits: Humans Language: Chinese Journal: Chinese Journal of Gastrointestinal Surgery Year: 2012 Type: Article