Microinjection of neuropeptide Y into periaqueductal grey produces anti-nociception in rats with mononeuropathy / 生理学报
Acta Physiologica Sinica
;
(6): 79-82, 2004.
Article
in English
| WPRIM
| ID: wpr-290885
ABSTRACT
The present study was carried out to investigate the effects of neuropeptide Y (NPY) in the midbrain periaqueductal grey (PAG) on the nociceptive modulation in mononeuropathic rats. NPY was microinjected into the PAG. The latency of paw withdrawal (PWL), assessed by the hot-plate (52 ) and the Randall Selitto test, was measured. Intra-PAG administration of 0.05, 0.1 and 0.2 nmol of NPY significantly increased the PWLs in a dose-dependent manner. Co-administration of 0.2 nmol of NPY(28-36) and 5.5 nmol of naloxone significantly attenuated the NPY-induced increase in PWLs. The results suggest that Y(1) receptor may mediate NPY-induced anti-nociception, and that the opioid receptors in PAG may also be involved in this process in mononeuropathic rats.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pain
/
Pharmacology
/
Physiology
/
Neuropeptide Y
/
Nociceptors
/
Periaqueductal Gray
/
Rats, Sprague-Dawley
/
Pain Threshold
/
Mononeuropathies
/
Analgesics
Limits:
Animals
Language:
English
Journal:
Acta Physiologica Sinica
Year:
2004
Type:
Article
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