Isoproterenol-induced activation of MAPK, NFkappaB and JAK/STAT pathway in mouse myocardium / 生理学报
Acta Physiologica Sinica
;
(6): 449-453, 2003.
Article
in Chinese
| WPRIM
| ID: wpr-290945
ABSTRACT
This study was aimed to determine the in vivo signal transduction pathway responsible for isoproterenol (ISO)-induced cardiac hypertrophy or remodeling. Mice were treated with ISO (15 mg/kg body weight) or vehicle by intraperitoneal injection (i.p.). Activation of mitogen-activted protein kinase (MAPK), NF-kappaB and JAK/STAT pathway in the left ventricular myocardium was measured by Western blot analysis. ISO significantly activated MAPK (ERK1/2 and p38) at early phase (5 min); biphasic activation of NF-kappaB was observed in our in vivo study; and ISO caused a delayed STAT3 activation (at 60 to 240 min) in mouse myocardium. Taken together, these results indicate that ISO activates these signal transduction pathways in different time course.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pharmacology
/
Time Factors
/
Signal Transduction
/
NF-kappa B
/
Mitogen-Activated Protein Kinases
/
STAT3 Transcription Factor
/
Janus Kinase 1
/
Heart
/
Isoproterenol
/
Metabolism
Limits:
Animals
Language:
Chinese
Journal:
Acta Physiologica Sinica
Year:
2003
Type:
Article
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