Responses of regional vascular beds to local injection of genistein in rats / 生理学报
Acta Physiologica Sinica
;
(6): 255-259, 2003.
Article
in English
| WPRIM
| ID: wpr-290976
ABSTRACT
The effects of local injection of genistein on femoral, renal, and mesenteric vascular beds were investigated respectively by constant flow perfusion method in 72 anaesthetized rats. The results are as follows (1) genistein (0.4, 0.8, 1.2 mg/kg) decreased the perfusion pressure (PP) of femoral vascular bed in a dose-dependent manner. The effect of genistein (0.8 mg/kg) was partially inhibited by L-NAME, or by sodium orthovanadate (50 microg/kg), a potent inhibitor of protein tyrosine phosphatase; (2) genistein also decreased the PP of renal vascular bed in a dose-dependent manner and the effect of genistein was completely inhibited by pretreatment with sodium orthovanadate, but unaffected by L-NAME; and (3) genistein decreased the PP of mesenteric vascular bed in a dose-dependent manner, an effect which was partially inhibited by sodium orthovanadate, but unaffected by L-NAME. From the results obtained, it is concluded that genistein can decrease the vascular tone in the femoral, renal, and mesenteric vascular beds with the underlying mechanism that involves tyrosine kinase inhibition, while in femoral arterial beds, it also involves NO release.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Perfusion
/
Pharmacology
/
Vasodilation
/
Protein-Tyrosine Kinases
/
Rats, Sprague-Dawley
/
Genistein
/
Protein Kinase Inhibitors
/
Hindlimb
/
Kidney
/
Mesentery
Limits:
Animals
Language:
English
Journal:
Acta Physiologica Sinica
Year:
2003
Type:
Article
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