Investigation of serum markers of hepatitis C virus in the hepatocellular carcinoma

ABSTRACT

100 patients with HCC, diagnosed by the clinical, Alpha Foetoprotein, imaging and cytological criteria; 50 patients in the control group. Anti HCV are performed by the techniques of EIA. HCV RNA is detected by RT PCR (reverse transcriptase PCR). The molecular biological techniques are performed at the Central Bio-medical laboratory in Hanoi Medical School. The frequency of serum anti HCV(ELISA) and especially of HCV RNA (RT-PCR) in the patients with HCC is also significantly higher than the one in the group of control Anti HCV and HCV RNA.The co infection HBV-HCV is not significant in the hepatocarcinogennesis in our study. This study showed that hepatitis B virus is an important etiologic factor in the hepatocarinogenesis in Thua Thien Hue. The role of HCV is also remarkable and the co infections HCV-HBV are not significant in our study