High cholesterol level upregulate the expression of caveolin-1 / 生物医学工程学杂志
Journal of Biomedical Engineering
;
(6): 276-279, 2004.
Article
in Chinese
| WPRIM
| ID: wpr-291131
ABSTRACT
To study the influence of hypercholesterolemia with caveolin-1 on the plasmalemma of vascular endothelium, we used the methods of immunohistochemistry to detect the dynamic changes of caveolin-1 in cultured ECV-304 cells which were stimulated high cholesterol serum and the arterial endothelium of hypercholesterolemia rats. It is resulted that high cholesteorol level can upregulate the expression of caveolin-1 both in vitro and in vivo. In the initial stage of hypercholesterolemia model, the expression of caveolin-1 increased as the time of high cholesterol level added, but in the later period it was decreased slightly.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Aorta
/
Pathology
/
Umbilical Veins
/
Blood
/
Endothelium, Vascular
/
Cells, Cultured
/
Cholesterol
/
Rats, Sprague-Dawley
/
Caveolins
/
Cell Biology
Limits:
Animals
/
Female
/
Humans
/
Male
Language:
Chinese
Journal:
Journal of Biomedical Engineering
Year:
2004
Type:
Article
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