Preparation and degradation of poly(DL-lactide)/calcium phosphates porous scaffolds / 生物医学工程学杂志
Journal of Biomedical Engineering
;
(6): 174-177, 2004.
Article
in Chinese
| WPRIM
| ID: wpr-291156
ABSTRACT
The porous foams were prepared by the solvent-casting and particulate-leaching technique using poly(DL-lactide) (PDLLA), poly(DL-lactide)/hydroxyapatite (PDLLA/20wt%HA), and poly(DL-lactide)/beta-tricalcium phosphate(PDLLA/20wt% beta-TCP) respectively. Observations by scanning electron microscopy indicated that the HA and beta-TCP were homogeneously dispersed in the polymer matrix, and the pores of the foams are interconnected, resulting in continuous pore structures. The porosity of PDLLA/HA and PDLLA/beta-TCP foams was lower than that of the pure PDLLA foams, but the compression strength was higher than that of the pure PDLLA foams. The results of the degradation in vitro showed that both HA and beta-TCP had significant inhibitory effects on the degradation of PDLLA, especially the HA. It is expected that the composite foams are of use as scaffolds for bone tissue engineering.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Polyesters
/
Polymers
/
Biocompatible Materials
/
Calcium Phosphates
/
Chemistry
/
Porosity
/
Durapatite
/
Bone Substitutes
/
Tissue Engineering
Language:
Chinese
Journal:
Journal of Biomedical Engineering
Year:
2004
Type:
Article
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