Effects of diffusion time and diffusion gradient magnetic field on the apparent diffusion coefficient of water molecules / 生物医学工程学杂志
Journal of Biomedical Engineering
;
(6): 542-546, 2008.
Article
in Chinese
| WPRIM
| ID: wpr-291195
ABSTRACT
Diffusion time and diffusion gradient magnetic strength are two important parameters of the pulsed gradient spin echo (PGSE) that is the most commonly used method in diffusion-weighted magnetic resonance imaging. However, the effects of the diffusion time on the apparent diffusion coefficient (ADC) in previous studies are controversial, and the effects of the diffusion gradient magnetic strength have received little attention. In this study, a new experimental protocol was designed to evaluate the effects of the two parameters on ADC. It was found that ADC decreased significantly with the increase of diffusion time or increase of diffusion gradient magnetic strength, which cannot be explained by the previous theories. Through theoretical analysis, we found the flaw of PGSE method, which is on explanation for the controversial results of diffusion time in former literatures.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Image Processing, Computer-Assisted
/
Water
/
Chemistry
/
Diffusion Magnetic Resonance Imaging
/
Diffusion
/
Electromagnetic Fields
/
Methods
Language:
Chinese
Journal:
Journal of Biomedical Engineering
Year:
2008
Type:
Article
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