Correlation between dissolution in vitro and absorption in vivo of chuanping sustained release tablets / 中国中药杂志
China Journal of Chinese Materia Medica
;
(24): 3473-3478, 2013.
Article
in Chinese
| WPRIM
| ID: wpr-291343
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the correlation between dissolution in vitro and absorption in vivo of Chuanping sustained release tablets.</p><p><b>METHOD</b>The ephedrine, pseudoephedrine were chosen as marker components, dissolution in vitro of Chuanping sustained release tablets in the different pH were tested by the rotating basket method and HPLC; urine drug levels were determined by HPLC and absorption fractions were calculated according to Wagner-Nelson's formula and deconvolution technique.</p><p><b>RESULT</b>The linear regressive equation between the absorption percentage in vivo F and accumulative release percentage in vitro of Chuanping sustained release tablets was established as F(ephedrine) = 1.572 5f-20. 729 (R2 = 0.974 5); F(pseudoephedrine) = 1.237f-0.147 6 (R2 = 0.959 5).</p><p><b>CONCLUSION</b>The results suggested that there was fine correlation between the absorption percentage in vivo and the accumulative release percentage in vitro of Chuanping sustained release tablets.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Solubility
/
Tablets
/
Drugs, Chinese Herbal
/
Pharmacokinetics
/
Chemistry
/
Chromatography, High Pressure Liquid
/
Delayed-Action Preparations
/
Ephedrine
Limits:
Adult
/
Female
/
Humans
/
Male
Language:
Chinese
Journal:
China Journal of Chinese Materia Medica
Year:
2013
Type:
Article
Similar
MEDLINE
...
LILACS
LIS