Cell origin of localized Castleman's disease of hyaline-vascular type / 中华血液学杂志
Chinese Journal of Hematology
;
(12): 397-400, 2004.
Article
in Chinese
| WPRIM
| ID: wpr-291408
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the cell features of 6 Castleman's disease patients and evaluate their prognosis.</p><p><b>METHODS</b>The resected tumors were investigated by routine histopathology and immunohistochemistry. Reverse-transcript PCR (RT-PCR) and sequencing of RT-PCR products were used to assess the clonal characters of the main tumor cells.</p><p><b>RESULTS</b>Histologically, all of the 6 tumors were classified as the hyaline vascular type. B-cells dominated the follicular germinal centers, with T-cells dispersing inter-follicularly. The results of RT-PCR each obtained a single band of either 128 bp or 122 bp and sequencing showed that there was highly homogeneity within the same length sequences, accompanied by fewer different nucleotide acids.</p><p><b>CONCLUSION</b>Monoclonal and/or oligoclonal B cells were identified in Castleman's disease. These B cells were originated from germinal center cells.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Prognosis
/
Immunohistochemistry
/
B-Lymphocytes
/
Gene Rearrangement, B-Lymphocyte, Heavy Chain
/
Castleman Disease
/
Clone Cells
/
Leukocyte Common Antigens
/
Antigens, CD20
/
Reverse Transcriptase Polymerase Chain Reaction
Type of study:
Prognostic study
Limits:
Adolescent
/
Adult
/
Female
/
Humans
/
Male
Language:
Chinese
Journal:
Chinese Journal of Hematology
Year:
2004
Type:
Article
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