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The study on the interactions between polycyclic aromatic hydrocarbon-albumin adducts and various risk factors to primary hepatocellular carcinoma / 中华预防医学杂志
Chinese Journal of Preventive Medicine ; (12): 427-432, 2010.
Article in Chinese | WPRIM | ID: wpr-291520
ABSTRACT
<p><b>OBJECTIVE</b>To explore the relationship between polycyclic aromatic hydrocarbon (PAH) exposure and hepatocellular carcinoma (HCC), and the interaction of PAH exposure and other HCC risk factors to HCC.</p><p><b>METHODS</b>Baseline blood samples, collected from 345 HCC cases and 961 controls, were used to determine the level of PAH-albumin adducts by competitive enzyme-linked immunosorbent assay. Conditional logistic regression analysis was used to assess the effect of PAH-albumin adducts on risk of HCC.</p><p><b>RESULTS</b>The mean level of PAH-albumin adducts was significantly higher in cases than in controls ((5.68 +/- 0.72) fmol/mg albumin vs (5.46 +/- 0.63) fmol/mg albumin) (u = 5.98, P < 0.01). When compared to subjects in the lowest quantile (< 1.76 fmol/mg albumin), there was an increase in risk of HCC, with adjusted ORs (95%CI) of 1.03 (0.65 - 1.60), 1.18 (0.76 - 1.78), 2.01 (1.42 - 2.82) for subjects in the second (1.76-fmol/mg albumin), the third (15.28-fmol/mg albumin), and the fourth quantile (> 34.21 fmol/mg albumin), respectively (chi(2)(trend) = 15.06, P < 0.01). There was a significant interaction between PAH-albumin adducts and HBsAg, family history of cancer and diabetes mellitus on HCC after adjusted for other risk factors, and relative excess risks due to the interaction (RERI) were 2.50 (u = 3.60, P < 0.01), 0.52 (u = 2.13, P < 0.05) and 0.88 (u = 2.26, P < 0.05), respectively.</p><p><b>CONCLUSION</b>PAH-albumin adducts was related with HCC, and there is a trend of HCC prevalence increasing with the content of PAH-albumin adducts. There are interactions between PAH-albumin adducts and HBV infection, family history of cancer and diabetes mellitus on HCC.</p>
Subject(s)
Full text: Available Index: WPRIM (Western Pacific) Main subject: Polycyclic Aromatic Hydrocarbons / Blood / Case-Control Studies / Epidemiology / Prevalence / Causality / Risk Factors / Carcinoma, Hepatocellular / Aflatoxins / Liver Neoplasms Type of study: Etiology study / Observational study / Prevalence study / Risk factors Limits: Adult / Aged / Female / Humans / Male Language: Chinese Journal: Chinese Journal of Preventive Medicine Year: 2010 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Polycyclic Aromatic Hydrocarbons / Blood / Case-Control Studies / Epidemiology / Prevalence / Causality / Risk Factors / Carcinoma, Hepatocellular / Aflatoxins / Liver Neoplasms Type of study: Etiology study / Observational study / Prevalence study / Risk factors Limits: Adult / Aged / Female / Humans / Male Language: Chinese Journal: Chinese Journal of Preventive Medicine Year: 2010 Type: Article