Polymorphisms of vascular diseases-related genes in Guangzhou Biobank Cohort Study / 中华预防医学杂志
Chinese Journal of Preventive Medicine
; (12): 65-69, 2010.
Article
in Zh
| WPRIM
| ID: wpr-291559
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To study the polymorphisms of cerebrovascular and cardiovascular disease genes using Taqman single nucleotide polymorphism (SNP) genotyping kits.</p><p><b>METHODS</b>A total of 2000 subjects were recruited from the Guangzhou Biobank Cohort Study (GBCS), and 15 SNPs were detected using Taqman SNP genotyping kits and an ABI 7900HT real time PCR system. The data were tested for the Hardy-Weinberg equilibrium, and then compared with the data of the Chinese population from the International HapMap Project (HapMap_HCN).</p><p><b>RESULTS</b>(1) All genotype data of the 15 SNPs were consistent with the Hardy-Weinberg rules. (2) The significant differences were observed among two SNPs, rs4220 and rs5368 and the HapMap_HCN (rs4220 28.2% vs 17.8%; chi(2) = 4.891, P = 0.028; rs5368 22.1% vs 32.2%, chi(2) = 5.137, P = 0.024). Comparing other gene bank data, such as AFD-CHN-PANEL, the Allele Frequency Database (ALFRED) and JBIC-allele, it would be most likely that our observations represent differences between the Northern and Southern populations in China.</p><p><b>CONCLUSION</b>Such Biobank study provided a useful platform for the study of the role of genetic and environmental determinants on cerebrovascular and cardiovascular disease.</p>
Full text:
1
Index:
WPRIM
Main subject:
Brain Diseases
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Cardiovascular Diseases
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China
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Epidemiology
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Cohort Studies
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Biological Specimen Banks
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Polymorphism, Single Nucleotide
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Asian People
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Genetic Association Studies
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Genetics
Type of study:
Etiology_studies
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Incidence_studies
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Observational_studies
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Prognostic_studies
Limits:
Humans
Country/Region as subject:
Asia
Language:
Zh
Journal:
Chinese Journal of Preventive Medicine
Year:
2010
Type:
Article