Strategies for elucidating functional significance of complex disease related loci / 中华预防医学杂志
Chinese Journal of Preventive Medicine
;
(12): 299-302, 2015.
Article
in Chinese
| WPRIM
| ID: wpr-291649
ABSTRACT
Genome-wide association studies (GWAS) have identified thousands of genetic loci associated with complex diseases or traits. However, the exact biological functions of these loci are largely unknown. Recent functional annotation indicates that the majority of disease/trait associated loci are concentrated in regulatory DNA of human genome. Expression quantitative trait loci (eQTL) analyses, chromosome conformation capture related methods and genome editing methods (such as CRISPR/Cas9) may facilitate the functional study of these loci. Research on noncoding RNAs and rare variants may improve the functional understanding. These efforts may promise translation of GWAS findings to clinical practices.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Genetic Predisposition to Disease
/
Quantitative Trait Loci
/
Genome-Wide Association Study
Type of study:
Prognostic study
Limits:
Humans
Language:
Chinese
Journal:
Chinese Journal of Preventive Medicine
Year:
2015
Type:
Article
Similar
MEDLINE
...
LILACS
LIS