Research progress on seroepidemiological study of enterovirus 71 and coxsackievirus A16 infection among children / 中华预防医学杂志
Chinese Journal of Preventive Medicine
;
(12): 184-188, 2015.
Article
in Chinese
| WPRIM
| ID: wpr-291654
ABSTRACT
Most common causative agents for hand, foot and mouth disease (HFMD) are enterovirus 71 (EV-A71) and coxsackievirus A16 (CV-A16). The symptomatic and asymptomatic cases could transmit the disease in population. Many sero-epidemiological surveys were launched to estimate the sero-incidence of EV-A71 and CV-A16 enterovirus, the susceptibility of different sub-population, and to observe the dynamics of neutralizing antibody. A literature search of sero-epidemiological study focused on EV-A71 or CV-A16 was conducted via PubMed and China Hospital Knowledge Database. Based on the 20 selected studies, the different age groups' antibody level, the susceptibility, the dynamics of antibody and sero-incidence of EV-A71 or CV-A16 were analyzed. From our results, the antibody level against EV-A71 or CV-A16 in neonates was associated with their mothers, which was similar with that of adults. The antibody level against EV-A71 or CV-A16 in neonates dropped to lowest level at one years-old, and started to dramatically increase until four years-old, and reached a plateau at five years-old. In conclusion, the infants aged 6-12 months were the priority group to receive vaccination when the EV-A71 vaccine is licensed in the future.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Seroepidemiologic Studies
/
China
/
Age Factors
/
Vaccination
/
Enterovirus
/
Enterovirus A, Human
/
Antibodies, Neutralizing
/
Adaptive Immunity
/
Immunity, Maternally-Acquired
/
Mothers
Limits:
Adult
/
Child
/
Humans
/
Infant
/
Infant, Newborn
Country/Region as subject:
Asia
Language:
Chinese
Journal:
Chinese Journal of Preventive Medicine
Year:
2015
Type:
Article
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