Association of cytochrome P450 2A6 gene polymorphisms with smoking behaviors:a Meta-analysis / 中华预防医学杂志
Chinese Journal of Preventive Medicine
;
(12): 172-177, 2015.
Article
in Chinese
| WPRIM
| ID: wpr-291657
ABSTRACT
<p><b>OBJECTIVE</b>A Meta-analysis was performed to assess the association of defective hepatic cytochrome P450 2A6 (CYP2A6) gene with smoking behaviors.</p><p><b>METHODS</b>All eligible studies published up to 2014 were searched out from PubMed, China National Knowledge Internet (CNKI), ISI Web of knowledge (ISI), vip citation databases (VIP), Chinese BioMedical Literature (CBM) and Elsevier Science Direct, searching words were "smok*","nicotine dependence","CYP2A6","cytochrome P450 2A6","polymorphism","mut*"and"varia*", while 436 articles were concluded. Meta-analysis was performed using Statal 3.1.</p><p><b>RESULTS</b>A total of ten studies were finally included. We didn't find a significant effect of defective CYP2A6 gene on smoking initiation (fixed effect model (FEM) OR = 0.90, 95%CI 0.78-1.03, I(2) = 25.8%), smoking persistence (random effect model (REM) OR = 0.85, 95%CI 0.59-1.23, I(2) = 66.3%) and smoking cessation (REM OR = 0.89, 95%CI 0.57-1.40, I(2) = 67.1%). But it showed a significant protective effect of CYP2A6*4 on smoking initiation (FEM OR = 0.78, 95%CI 0.61-0.99, I(2) = 28.2%), smoking persistence (FEM OR = 0.53, 95%CI 0.36-0.77, I(2) = 41.0%) and smoking cessation (REM OR = 0.49, 95%CI 0.31-0.80, I(2) = 0.0%).</p><p><b>CONCLUSIONS</b>This Meta-analysis suggested that there was not a protective effect of defective CYP2A6 gene against smoking behaviors. But smokers with whole CYP2A6 gene deletion would be less likely to start smoking, less smoking persistence and more likely to quit smoking successful than smokers with wild CYP2A6 gene.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Polymorphism, Genetic
/
Tobacco Use Disorder
/
Aryl Hydrocarbon Hydroxylases
/
Smoking
/
China
/
Smoking Cessation
/
Gene Deletion
/
Asian People
/
Cytochrome P-450 CYP2A6
/
Protective Factors
Type of study:
Prognostic study
/
Systematic reviews
Limits:
Humans
Country/Region as subject:
Asia
Language:
Chinese
Journal:
Chinese Journal of Preventive Medicine
Year:
2015
Type:
Article
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