Research progress of TSPY1 gene family / 中华医学遗传学杂志
Chinese Journal of Medical Genetics
;
(6): 600-603, 2014.
Article
in Chinese
| WPRIM
| ID: wpr-291721
ABSTRACT
TSPY1 (testis-specific protein, Y-linked 1) gene family, located in male-specific region of Y-chromosome (MSY), has the maximum number of copies organized as a long tandem repeat array in protein-coding gene families of human genome. TSPY1 is identified to be the most important candidate gene for gonadoblastoma, and its coding protein can promote the proliferation and differentiation of tumor cells. Recently, TSPY1 gene family is also proposed to play an important role in spermatogenesis. In this review, the structure characteristics of the gene family were illustrated, and the functional studies of TSPY1 in the process of tumorigenesis and spermatogenesis were discussed.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Spermatogenesis
/
Testicular Neoplasms
/
Gonadoblastoma
/
Gene Dosage
/
Cell Cycle Proteins
/
Genetic Predisposition to Disease
/
Chromosomes, Human, Y
/
Genetics
Type of study:
Prognostic study
Limits:
Humans
/
Male
Language:
Chinese
Journal:
Chinese Journal of Medical Genetics
Year:
2014
Type:
Article
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