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Association study of LIS1 and TSNAX genes with bipolar disorder in Chinese Han population / 中华医学遗传学杂志
Chinese Journal of Medical Genetics ; (6): 357-361, 2014.
Article in Chinese | WPRIM | ID: wpr-291772
ABSTRACT
<p><b>OBJECTIVE</b>To assess the association of neural development-related genes LIS1and TSNAX with bipolar disorder in a Chinese Han population.</p><p><b>METHODS</b>Three hundred and eight five patients (including 188 males and 197 females) from Guangzhou Brain Hospital with bipolar disorder meeting the Diagnostic and Statistic Manual of Bipolar Disorder (BDI) (Fourth Edition) criteria and 475 healthy controls from the local community were recruited. Ten single nucleotide polymorphisms (SNPs) of the LIS1 and TSNAX genes were genotyped by GoldenGate genotyping assay on an Illumina Beadstation 500 machine. Association analyses of SNPs and haplotypes were performed with Plink 1.07 software.</p><p><b>RESULTS</b>Analysis of the total sample has failed to find any association of SNP or haplotype of the two genes with BDI (P> 0.05). When patients were divided into subgroups with or without psychotic symptom, no significant association of the two genes was found with psychotic BDI or non-psychotic BDI (P> 0.05). No significant association was found between any SNP and haplotype of two genes and female BDI or male BDI, nor were significant association found between age of onset and LIS1 and TSNAX gene polymorphisms.</p><p><b>CONCLUSION</b>Our results indicated that LIS1 and TSNAX genes are not associated with susceptibility to bipolar I disorder in Chinese Han population.</p>
Subject(s)
Full text: Available Index: WPRIM (Western Pacific) Main subject: Bipolar Disorder / Case-Control Studies / Genetic Predisposition to Disease / Polymorphism, Single Nucleotide / 1-Alkyl-2-acetylglycerophosphocholine Esterase / Asian People / DNA-Binding Proteins / Ethnology / Genetics / Genotype Type of study: Practice guideline / Observational study / Risk factors Limits: Adolescent / Adult / Aged / Aged80 / Female / Humans / Male Language: Chinese Journal: Chinese Journal of Medical Genetics Year: 2014 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Bipolar Disorder / Case-Control Studies / Genetic Predisposition to Disease / Polymorphism, Single Nucleotide / 1-Alkyl-2-acetylglycerophosphocholine Esterase / Asian People / DNA-Binding Proteins / Ethnology / Genetics / Genotype Type of study: Practice guideline / Observational study / Risk factors Limits: Adolescent / Adult / Aged / Aged80 / Female / Humans / Male Language: Chinese Journal: Chinese Journal of Medical Genetics Year: 2014 Type: Article