Studies on DNA damage in workers with long-term exposure to lower concentration of carbon disulfide / 中华预防医学杂志
Chinese Journal of Preventive Medicine
;
(12): 36-38, 2004.
Article
in Chinese
| WPRIM
| ID: wpr-291817
ABSTRACT
<p><b>OBJECTIVE</b>DNA damage in human buccal cells of workers occupationally long-term exposed to carbon disulfide (CS(2)) was monitored with comet assay.</p><p><b>METHODS</b>Ninety workers exposed to CS(2) were randomly selected as exposure group from a large-scale chemical fiber manufacturer in Hubei and 81 workers not exposed to CS(2) as control group. DNA damage in their buccal cells was detected with comet assay.</p><p><b>RESULTS</b>Rate of DNA tail was 0.51% in exposure group, significantly higher than that in control group (0.23%), with very statistical significance. Rate of DNA tail was 0.50% in male exposure group and 0.56% in exposure group with short length of employment, significantly higher than that in control group (0.08% and 0.25%, respectively). Multivariate unconditional logistic regression analysis showed that possibility of DNA damage was significantly higher in exposure group than that in control group (P < 0.05).</p><p><b>CONCLUSION</b>Long-term exposure to lower concentration of carbon disulfide could cause certain damage to human buccal cell DNA.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Poisoning
/
Time Factors
/
DNA Damage
/
DNA
/
Carbon Disulfide
/
Case-Control Studies
/
Logistic Models
/
Multivariate Analysis
/
Risk Factors
/
Occupational Exposure
Type of study:
Etiology study
/
Observational study
/
Prognostic study
/
Risk factors
Limits:
Adult
/
Female
/
Humans
/
Male
Language:
Chinese
Journal:
Chinese Journal of Preventive Medicine
Year:
2004
Type:
Article
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