Biological characteristics of breast carcinomas with neuroendocrine cell differentiation / 中华医学杂志(英文版)
Chinese Medical Journal
;
(24): 1536-1540, 2004.
Article
in English
| WPRIM
| ID: wpr-291885
ABSTRACT
<p><b>BACKGROUND</b>The aim of this study was to investigate DNA content and expression of c-erbB-2, PS2, and prostate-specific antigen (PSA) proteins in breast carcinomas with neuroendocrine (NE) cell differentiation.</p><p><b>METHODS</b>Chromogranin, c-erbB-2, PS2, and PSA in 131 samples of breast cancer were detected immunohistochemically. Classic Feulgen staining image analysis techniques were used to quantify DNA content in 81 of the breast cancer samples.</p><p><b>RESULTS</b>The c-erbB-2 positive rate in breast carcinoma samples containing neuroendocrine cells was 37.5% and the rate of high expression of c-erbB-2 (++ or +++) was 33.3%, both significantly lower than that in breast carcinomas without neuroendocrine cells (62.6% and 68.7%, respectively, P < 0.05). The rates of positive PS2 and PSA expression in breast carcinoma samples containing neuroendocrine cells were 72.2% and 55.0%, respectively, both significantly higher than that in breast carcinoma samples without neuroendocrine cells (45.0% and 16.4%, respectively, P < 0.05). In NE(+) samples, the integral optical density, DNA index, DNA stemline peak, > 5 c aneuploidy cells, and rate of aneuploidy among cells were all lower than that in NE(-) breast carcinomas (P < 0.01). In NE(+) grade I or II breast carcinomas, these indices were also all lower than that in the NE(-) breast carcinoma samples (P < 0.01).</p><p><b>CONCLUSION</b>Breast carcinomas with neuroendocrine differentiation have a lower rate of malignancy. Neuroendocrine differentiation could serve as a prognostic marker in clinical practice.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Breast Neoplasms
/
DNA
/
Cell Differentiation
/
Chemistry
/
Prostate-Specific Antigen
/
Receptor, ErbB-2
/
Cell Biology
/
Presenilin-2
/
Membrane Proteins
Type of study:
Prognostic study
Limits:
Female
/
Humans
Language:
English
Journal:
Chinese Medical Journal
Year:
2004
Type:
Article
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