Genetic polymorphism in matrix metalloproteinase-9 and the susceptibility to chronic obstructive pulmonary disease in Han population of south China / 中华医学杂志(英文版)
Chinese Medical Journal
;
(24): 1481-1484, 2004.
Article
in English
| WPRIM
| ID: wpr-291895
ABSTRACT
<p><b>BACKGROUND</b>There are many candidate genes for chronic obstructive pulmonary disease (COPD). Matrix metalloproteinase-9 (MMP-9) plays an essential role in tissue remodeling and repair associated with development of COPD. In this study we investigated the correlation between MMP-9 gene polymorphism and COPD susceptibility in the Han population of South China.</p><p><b>METHODS</b>We examined the frequency of polymorphic genotypes of the MMP-9 promoter (-1562C/T) in 100 COPD patients and 98 healthy smokers by restriction fragment length polymorphism.</p><p><b>RESULTS</b>The frequencies of polymorphic genotypes in promoters of MMP-9 were C/C 86%, C/T 14% in COPD group; and C/C 98%, C/T 2% in the control group. There were significant differences between the two groups (P < 0.01). The allele frequencies were also significantly different between the COPD group and the control group (C allele frequency 93% vs 99%, T allele frequency 7% vs 1%, P < 0.05 respectively).</p><p><b>CONCLUSION</b>The genetic polymorphism in promoters of MMP-9 gene is associated with the susceptibility to COPD in the Han population of South China.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Polymorphism, Genetic
/
China
/
Promoter Regions, Genetic
/
Genetic Predisposition to Disease
/
Matrix Metalloproteinase 9
/
Pulmonary Disease, Chronic Obstructive
/
Ethnology
/
Gene Frequency
/
Genetics
/
Genotype
Limits:
Adult
/
Aged
/
Female
/
Humans
/
Male
Country/Region as subject:
Asia
Language:
English
Journal:
Chinese Medical Journal
Year:
2004
Type:
Article
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