The characteristics of PCNA expression in hypertrophic scars and chronic ulcers and implication of the expression / 中华整形外科杂志

ABSTRACT

<p><b>OBJECTIVE</b>To investigate the characteristics of PCNA expression in hypertrophic scars and chronic ulcers and to discuss its relation to their formation.</p><p><b>METHODS</b>The expressive quantity and sites of PCNA were detected with the immunohistochemical SP method.</p><p><b>RESULTS</b>PCNA was expressed in all samples. The expressive quantity in hypertrophic scars was higher than chronic ulcers(P < 0.01). The expressive sites of all samples were in the nucleus of fibroblasts and capillary endothelial cells.</p><p><b>CONCLUSIONS</b>The expressive quantity of PCNA was more in hypertrophic scars and less n chronic ulcers. The quantitative difference of expression between hypertrophic scars and chronic ulcers may be correlated to their formation.</p>