Progress in using Newcastle disease virus for tumor therapy: a review / 生物工程学报
Chinese Journal of Biotechnology
;
(12): 1031-1036, 2010.
Article
in Chinese
| WPRIM
| ID: wpr-292175
ABSTRACT
Naturally existing Newcastle disease virus (NDV) can specifically execute oncolytic ability in clinical studies. Reports from clinical trials using NDV as oncolytic agents showed promise and warrant results in cancer therapy. In recent years, reverse genetics technology has been used widely in the studies of NDV virology. More recently, the technology was applied to optimize the oncolytic efficacy of NDV, for instance, modification of the F gene, and expression of GM-CSF, IFN-gamma, IL-2 or TNF-alpha. NDV is widely investigated in cancer therapy and will definitely offer a prosperous future for clinical cancer therapeutics. We reviewed the developments of cancer therapy by recombinant NDV using reverse genetics technology, as well as our own experience in this domain.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Physiology
/
Recombination, Genetic
/
Therapeutics
/
Newcastle disease virus
/
Oncolytic Viruses
/
Oncolytic Virotherapy
/
Genetics
/
Methods
/
Neoplasms
Limits:
Animals
/
Humans
Language:
Chinese
Journal:
Chinese Journal of Biotechnology
Year:
2010
Type:
Article
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