Progress in application of targeting viral vector regulated by microRNA in gene therapy: a review / 生物工程学报
Chinese Journal of Biotechnology
;
(12): 707-714, 2010.
Article
in Chinese
| WPRIM
| ID: wpr-292217
ABSTRACT
A safe and effective targeting viral vector is the key factor for successful clinical gene therapy. microRNA, a class of small, single-stranded endogenous RNAs, act as post-transcriptional regulators of gene expression. The discovery of these kind regulatory elements provides a new approach to regulate gene expression more accurately. In this review, we elucidated the principle of microRNA in regulation of targeting viral vector. The applications of microRNA in the fields of elimination contamination from replication competent virus, reduction of transgene-specific immunity, promotion of cancer-targeted gene therapy and development of live attenuated vaccines were also discussed.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Viruses
/
Genetic Therapy
/
Gene Expression Regulation
/
MicroRNAs
/
Genetic Vectors
/
Genetics
/
Metabolism
Limits:
Humans
Language:
Chinese
Journal:
Chinese Journal of Biotechnology
Year:
2010
Type:
Article
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