Expression of Versican and its clinical significance in gastric carcinoma / 中华病理学杂志
Chinese Journal of Pathology
;
(12): 473-477, 2014.
Article
in Chinese
| WPRIM
| ID: wpr-292260
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the expression of Versican in gastric carcinoma and its relationship with tumor angiogenesis.</p><p><b>METHODS</b>Protein expression of Versican, vascular endothelial growth factor and CD34 was evaluated by immunohistochemistry (EliVision method) in 80 cases of gastric carcinoma and 30 samples of normal gastric tissue.</p><p><b>RESULTS</b>There were statistically significant differences in the expression of Versican, vascular endothelial growth factor and CD34 between gastric carcinoma and normal gastric tissue (P < 0.05). The expression of Versican was seen mainly in fibroblasts of the tumor and was correlated with tumor differentiation, clinical stage and lymph node metastasis (P < 0.05), whereas vascular endothelial growth factor was primarily seen in the cytoplasm of the tumor cells and correlated with tumor differentiation, clinical stage, Lauren classification and lymph node metastasis (P < 0.05). MVD was correlated with tumor differentiation, clinical stage, Lauren classification, depth of tumor invasion and lymph node metastasis (P < 0.05). In addition, positive correlation of Versican and VEGF protein expression was found in tumor cells (r = 0.467, P < 0.01).</p><p><b>CONCLUSION</b>The expression of both Versican and vascular endothelial growth factor is closely associated with tumor angiogenesis in gastric carcinoma.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Prognosis
/
Stomach
/
Stomach Neoplasms
/
Immunohistochemistry
/
Antigens, CD34
/
Vascular Endothelial Growth Factor A
/
Versicans
/
Fibroblasts
/
Lymphatic Metastasis
Type of study:
Prognostic study
Limits:
Humans
Language:
Chinese
Journal:
Chinese Journal of Pathology
Year:
2014
Type:
Article
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