Evaluation of c-myc and CCNE2 amplification in breast cancer with quantitative multi-gene fluorescence in-situ hybridization / 中华病理学杂志
Chinese Journal of Pathology
;
(12): 455-458, 2014.
Article
in Chinese
| WPRIM
| ID: wpr-292264
ABSTRACT
<p><b>OBJECTIVE</b>To investigate c-myc and CCNE2 gene amplifications and their relationship in breast cancer.</p><p><b>METHODS</b>Sixty-six infiltrating ductal breast carcinomas with foci of ductal carcinoma in situ components collected from January 2005 to December 2007 were selected for tissue microarray and quantitative multi-gene FISH for c-myc and CCNE2 gene amplification, and the relationship with the clinicopathologic features was analyzed.</p><p><b>RESULTS</b>Of the 66 cases, 18 (27.3%) showed c-myc amplification and 23 (34.8%) showed CCNE2 amplification. A strong correlation was found between c-myc and CCNE2 amplification (P < 0.01). The breast cancers showing c-myc and CCNE2 amplifications were all aneuploidy, and were HER2 positive (P < 0.05). Tumors with c-myc amplification also showed higher Ki-67 index (P < 0.05).</p><p><b>CONCLUSIONS</b>C-myc and CCNE2 amplifications are common events in breast cancer, and they often coexist. C-myc and CCNE2 genes may play critical roles in the pathogenesis and development of breast cancer through unique and overlapping signaling pathways.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Breast Neoplasms
/
Carcinoma in Situ
/
Gene Amplification
/
Genes, myc
/
In Situ Hybridization, Fluorescence
/
Cyclins
/
Carcinoma, Ductal, Breast
/
Carcinoma, Intraductal, Noninfiltrating
/
Tissue Array Analysis
/
Genetics
Limits:
Female
/
Humans
Language:
Chinese
Journal:
Chinese Journal of Pathology
Year:
2014
Type:
Article
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