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Prognostic significance of mutually exclusive expression of ERG and SPINK1 in endocrine-treated prostatic cancer / 中华病理学杂志
Chinese Journal of Pathology ; (12): 149-153, 2014.
Article in Chinese | WPRIM | ID: wpr-292339
ABSTRACT
<p><b>OBJECTIVE</b>To study the expression and prognostic significance of ERG and SPINK1 expression in endocrine-treated prostatic cancer.</p><p><b>METHODS</b>Prostatic needle biopsies from 118 prostatic cancer patients primarily treated with endocrine therapy were reviewed. Immunohistochemical study for ERG and SPINK1 protein was carried out.</p><p><b>RESULTS</b>Co-expression of ERG and SPINK1 was not observed. The frequency of ERG protein expression in the 118 biopsies studied was 9.3% (11/118). The positive expression correlated with T stage (P=0.04) but not with patient age at diagnosis, prostatic specific antigen level, Gleason's score, M stage, tumor area and progression-free survival. Positive expression of SPINK1 was demonstrated in 11.0% (13/118) of the biopsies. SPINK1-positive cases carried a significantly shorter progression-free survival, as compared with SPINK1-negative cases (P=0.022). The expression was not associated with any other clinicopathologic variables. The following expression pattern showed statistically significant correlation with the clinical progress (P=0.029) ERG+/SPINK1- (11/118, 9.3%), ERG-/SPINK1+ (13/118, 11.0%) and ERG-/SPINK1- (94/118, 79.7%).</p><p><b>CONCLUSIONS</b>ERG and SPINK1 proteins are mutually exclusive.SPINK1 expression is associated with more aggressive clinical behavior and can serve as a prognostic biomarker in prostatic cancer.</p>
Subject(s)
Full text: Available Index: WPRIM (Western Pacific) Main subject: Pathology / Prognosis / Prostatic Neoplasms / Immunohistochemistry / Carrier Proteins / Trans-Activators / Trypsin Inhibitor, Kazal Pancreatic / Follow-Up Studies / Disease-Free Survival / Antineoplastic Agents, Hormonal Type of study: Observational study / Prognostic study Limits: Aged / Aged80 / Humans / Male Language: Chinese Journal: Chinese Journal of Pathology Year: 2014 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Pathology / Prognosis / Prostatic Neoplasms / Immunohistochemistry / Carrier Proteins / Trans-Activators / Trypsin Inhibitor, Kazal Pancreatic / Follow-Up Studies / Disease-Free Survival / Antineoplastic Agents, Hormonal Type of study: Observational study / Prognostic study Limits: Aged / Aged80 / Humans / Male Language: Chinese Journal: Chinese Journal of Pathology Year: 2014 Type: Article