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Amlodipine combined with terazosin reduces postvoid residual and the risk of acute urinary retention / 中华男科学杂志
National Journal of Andrology ; (12): 441-444, 2009.
Article in Chinese | WPRIM | ID: wpr-292355
ABSTRACT
<p><b>OBJECTIVE</b>This prospective randomized double-blinded clinical trial was designed to explore the effects of amlodipine and the combination of amlodipine with terazosin in improving postvoid residual (PVR) in patients with lower urinary tract symptoms (LUTS) and concomitant hypertension.</p><p><b>METHODS</b>We randomly divided 360 LUTS patients with concomitant hypertension into a 5 mg amlodipine group, a 2 mg terazosin group and a 5 mg amlodipine plus 2 mg terazosin group, and measured PVR at the baseline and 4 weeks after the treatment.</p><p><b>RESULTS</b>For male patients with LUTS associate with hypertension, all of amlodipine (APVR = 6.8) , terazosin (APVR = 7. 6), and combination group (APVR = 8.8) can significant reduced the PVR (P < . 0.1), but no significant difference was found among three groups.</p><p><b>CONCLUSION</b>Amlodipine alone or combined with terazosin can improve the PVR of the LUTS patient effectively, but had no significant difference compared with terazosin.</p>
Subject(s)
Full text: Available Index: WPRIM (Western Pacific) Main subject: Prostatic Hyperplasia / Urodynamics / Prazosin / Double-Blind Method / Prospective Studies / Urinary Retention / Treatment Outcome / Amlodipine / Adrenergic alpha-Antagonists / Therapeutic Uses Type of study: Controlled clinical trial / Etiology study / Observational study / Risk factors Limits: Aged / Humans / Male Language: Chinese Journal: National Journal of Andrology Year: 2009 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Prostatic Hyperplasia / Urodynamics / Prazosin / Double-Blind Method / Prospective Studies / Urinary Retention / Treatment Outcome / Amlodipine / Adrenergic alpha-Antagonists / Therapeutic Uses Type of study: Controlled clinical trial / Etiology study / Observational study / Risk factors Limits: Aged / Humans / Male Language: Chinese Journal: National Journal of Andrology Year: 2009 Type: Article