Magnetic resonance spectroscopy on hepatocellular carcinoma after transcatheter arterial chemoembolization / 癌症
Chinese Journal of Cancer
;
(12): 198-201, 2010.
Article
in English
| WPRIM
| ID: wpr-292610
ABSTRACT
<p><b>BACKGROUND AND OBJECTIVE</b>Proton magnetic resonance spectroscopy (MRS) of the liver in vivo is in experimental phase. MRS observation on liver cancer after transcatheter arterial chemoembolization (TACE) has seldom been reported. This study was to investigate the value of MRS in assessing the metabolic changes of hepatocellular carcinoma (HCC) after TACE.</p><p><b>METHODS</b>Twenty-five consecutive patients with pathologically-confirmed HCC received 1H MRS of all hepatic lesions using 1.5T whole body MR scanner before TACE and at 3-10 days after TACE. Choline-to-lipid (Cho/Lip), glucogen/glucose-to-lipid (Glu/Lip), and glytamine/glutamate-to-lipid (Glx/Lip) ratios were measured and analyzed statistically.</p><p><b>RESULTS</b>The Cho/Lip, Glu/Lip, and Glx/Lip ratios were 0.21 +/- 0.08, 0.11 +/- 0.05, 0.28 +/- 0.10 before TACE, respectively, and were 0.10 +/- 0.08, 0.07 +/- 0.07, 0.18 +/- 0.12 after TACE, respectively, with significant differences (P < 0.05).</p><p><b>CONCLUSIONS</b>Using MRS can evaluate the early metabolic responses of HCC to TACE.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Therapeutics
/
Magnetic Resonance Spectroscopy
/
Choline
/
Chemoembolization, Therapeutic
/
Carcinoma, Hepatocellular
/
Glutamic Acid
/
Glucose
/
Glutamine
/
Glycogen
/
Lipids
Limits:
Adult
/
Aged
/
Female
/
Humans
/
Male
Language:
English
Journal:
Chinese Journal of Cancer
Year:
2010
Type:
Article
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