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Comparison of the short-term efficacy of two inductive chemotherapy regimens for locally advanced nasopharyngeal caricinoma: docetaxal plus carboplatin versus 5-fluorouracil plus carboplatin / 癌症
Chinese Journal of Cancer ; (12): 140-144, 2010.
Article in English | WPRIM | ID: wpr-292621
ABSTRACT
<p><b>BACKGROUND AND OBJECTIVE</b>The platinum-based chemotherapy combined with 5-fluorouracil (5-FU) is most frequently used for nasopharyngeal carcinoma (NPC), but the efficacy has been maintained at 50%-60%. Docetaxel is an effective drug for head and neck tumors, its administration is simple, and the administration time is short. This study was to compare the short-term efficacy and toxicity between TC regimen (inductive chemotherapy with docetaxol plus carboplatin) and FC regimen (5-FU plus carboplatin) in local advanced NPC so as to provide a new chemotherapeutic regimen for NPC.</p><p><b>METHODS</b>Fifty-eight local advanced NPC patients without previous treatment in Sun Yat-sen University Cancer Center were randomly assigned to receive either TC or FC regimen inductive chemotherapy, followed by concurrent chemoradiotherapy with two cycles of carboplatin (AUC=6) plus radiotherapy of 60-78 Gy to the nasopharynx and 60-70 Gy to the neck. The short-term efficacy and adverse events were observed.</p><p><b>RESULTS</b>More chemotherapy cycles were finished in TC group than in FC group (3.31 vs. 2.83, P = 0.043). There was no significant difference in short-term efficacy and 1-year survival rate between the two groups (P > 0.05). More grades 3-4 neutropenia appeared in TC group than in FC group (72.4% vs. 37.9%, P < 0.05) , whereas less thrombocytopenia and emesis occurred in TC than in FC group (P = 0.013 and 0.018, respectively).</p><p><b>CONCLUSIONS</b>The short-term efficacy of TC regimen in local advanced NPC is similar to that of FC regimen with tolerable adverse events. But the long-term outcomes and toxicities need to be further investigated.</p>
Subject(s)
Full text: Available Index: WPRIM (Western Pacific) Main subject: Pathology / Thrombocytopenia / Vomiting / Antineoplastic Combined Chemotherapy Protocols / Nasopharyngeal Neoplasms / Survival Rate / Carboplatin / Taxoids / Therapeutic Uses / Drug Therapy Limits: Adult / Female / Humans / Male Language: English Journal: Chinese Journal of Cancer Year: 2010 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Pathology / Thrombocytopenia / Vomiting / Antineoplastic Combined Chemotherapy Protocols / Nasopharyngeal Neoplasms / Survival Rate / Carboplatin / Taxoids / Therapeutic Uses / Drug Therapy Limits: Adult / Female / Humans / Male Language: English Journal: Chinese Journal of Cancer Year: 2010 Type: Article