Expression of drug resistance and metastasis related gene in adenoid cystic carcinoma and mucoepidermoid carcinoma / 中华口腔医学杂志
Chinese Journal of Stomatology
;
(12): 78-79, 2007.
Article
in Chinese
| WPRIM
| ID: wpr-292960
ABSTRACT
<p><b>OBJECTIVE</b>To examine the differential gene expression among adenoid cystic carcinoma ACC-M, low metastasis ACC-2 and low differentiated mucoepidermoid carcinoma MEC-1 with gene array, and detect three important genes with real-time quantitative PCR.</p><p><b>METHODS</b>Gene array was used to screen the differential genes, then three important genes were selected and detected by real-time quantitative PCR.</p><p><b>RESULTS</b>The gene contents of MDR-1, MRP-1 and CCD1 were MEC-1 > ACC-M > ACC-2, MEC-1 > ACC-M > ACC-2 and MEC-1 > ACC-M > ACC-2 respectively.</p><p><b>CONCLUSIONS</b>Drug resistance of MEC-1 is related with high content of MDR-1. High metastasis of ACC-M is concerned with high content of MRP-1 and low content of CCD-1. Low metastasis of ACC-2 has a relationship with low content of MRP1.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Salivary Gland Neoplasms
/
Gene Expression Regulation, Neoplastic
/
Polymerase Chain Reaction
/
Carcinoma, Mucoepidermoid
/
Carcinoma, Adenoid Cystic
/
Drug Resistance, Neoplasm
/
Genes, MDR
/
Oligonucleotide Array Sequence Analysis
/
Cell Line, Tumor
/
Genetics
Limits:
Humans
Language:
Chinese
Journal:
Chinese Journal of Stomatology
Year:
2007
Type:
Article
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