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Network pharmacology study on major active compounds of Fufang Danshen formula / 中国中药杂志
China Journal of Chinese Materia Medica ; (24): 2911-2915, 2011.
Article in Chinese | WPRIM | ID: wpr-293153
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the correlations between multi-compounds of Fufang Danshen formula and their multi targets and multi diseases.</p><p><b>METHOD</b>Literature knowledge of nine major active compounds from Fufang Danshen formula, including tanshinone II(A), salvianolic acid B, protocatechuic aldehyde, danshensu, cryptotanshinone, notoginsenoside R1, ginsenoside Rg1, ginsenoside Rb1 and borneol were collected from PubMed. Combined with cardiovascular related diseases and genes from OMIM database, the corresponding multi-compound-multi- target-multi-disease network was constructed and visualized by Cytoscape software.</p><p><b>RESULT</b>AND

CONCLUSION:

Network analysis showed that the 9 compounds could modulate 42 cardiovascular associated genes (e. g. PPARG, ACE, KCNJ11, KCNQ1, ABCC8, et al), which related to 30 cardiovascular associated diseases including non-insulin-dependent diabetes mellitus, hyperinsulinemic hypoglycemia, hypertension, and coronary heart disease. These results suggested new potential indications of Fufang Danshen formula.</p>
Subject(s)
Full text: Available Index: WPRIM (Western Pacific) Main subject: Pharmacology / Drugs, Chinese Herbal / Chemistry / Disease / Salvia miltiorrhiza / Drug Therapy / Gene Regulatory Networks / Genetics Limits: Animals / Humans Language: Chinese Journal: China Journal of Chinese Materia Medica Year: 2011 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Pharmacology / Drugs, Chinese Herbal / Chemistry / Disease / Salvia miltiorrhiza / Drug Therapy / Gene Regulatory Networks / Genetics Limits: Animals / Humans Language: Chinese Journal: China Journal of Chinese Materia Medica Year: 2011 Type: Article