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Research and development of the effective components of panaxdiol saponin as new Chinese patent medicine for treating hemocytopenia / 中国结合医学杂志
Chinese journal of integrative medicine ; (12): 897-902, 2012.
Article in English | WPRIM | ID: wpr-293328
ABSTRACT
Pancytopenia (hemocytopenia) such as pr imary immune primary thrombocytopenia (ITP), aplastic anemia and chronic neutropenia (agnogenic leukocytopenia) were of ten t reated by glucocor t icoids, androgen and often treated glucocorticoids, immunosuppressive agents at present, but the response to these treatments has not been always satisfactory, and may cause serious adverse events. Our research has identified a biological active component in ginseng extract and the active component, panaxadiol saponins component (PDS-C), was isolated from total saponins of ginsenosides, and formulated into capsules named as Painengda. We successfully obtained approval from State Food and Drug Administration (SFDA) of China in 2010 to conduct clinical trials of PDS-C as class-five new Chinese patent medicine. Phase I and phase II clinical trials of PDS-C and Painengda Capsule were carried out in the treatment of ITP and agnogenic leukocytopenia. The composition and content of PDS-C have been analyzed and defined by high-performance liquid chromatography-chromatographymass spectrometry (HPLC-MS) and HPLC using specific monomers of ginsenosides as the reference standards. mass PDS-C is very efficacious for treating mice and rats with ITP and aplastic anemia, and myelosuppression caused by chemotherapy or radiation. Our animal model studies and cell biology and molecular biology experiments demonstrated that PDS-C possessed dual activities, namely that of promoting proliferation and differentiation of hematopoietic progenitor cells, and that of regulating the immune function. PDS-C and Painengda Capsule as a new Chinese patent medicine have been successfully transferred to industry. We believe that PDS-C is effective and safe in the treatment of refractory hemocytopenia. The advantages are that it is effective in small doses, it is convenient to use because of its oral administration, its lack of adverse events, it could be used alone or in combination with pharmacological agents, which improve the efficacy and decrease adverse events.
Subject(s)
Full text: Available Index: WPRIM (Western Pacific) Main subject: Pancytopenia / Saponins / Chemistry / Clinical Trials as Topic / Purpura, Thrombocytopenic, Idiopathic / Therapeutic Uses / Disease Models, Animal / Drug Therapy / Anemia, Aplastic / Medicine, Chinese Traditional Type of study: Diagnostic study / Practice guideline Limits: Animals / Humans Language: English Journal: Chinese journal of integrative medicine Year: 2012 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Pancytopenia / Saponins / Chemistry / Clinical Trials as Topic / Purpura, Thrombocytopenic, Idiopathic / Therapeutic Uses / Disease Models, Animal / Drug Therapy / Anemia, Aplastic / Medicine, Chinese Traditional Type of study: Diagnostic study / Practice guideline Limits: Animals / Humans Language: English Journal: Chinese journal of integrative medicine Year: 2012 Type: Article