Effect of simvastatin on monocyte CX3CR1 expression in patients with acute coronary syndrome / 南方医科大学学报
Journal of Southern Medical University
;
(12): 475-477, 2008.
Article
in Chinese
| WPRIM
| ID: wpr-293348
ABSTRACT
<p><b>OBJECTIVE</b>To observe the effect of simvastatin on expression of CX3CR1 in the monocytes in patients with acute coronary syndrome and investigate the non-lipid mechanisms of statins against atherosclerosis.</p><p><b>METHODS</b>The expression of CX3CR1 in the monocytes was measured by quantitative real-time RT-PCR in 63 patients with acute coronary syndrome confirmed by coronary arteriography after treatment with simvastatin at 10(-7) approximately 10(-5) mol/L for 4, 8 and 12 h, respectively.</p><p><b>RESULTS</b>CX3CR1 expression in the monocytes treated with different concentrations of simvastatin was significantly lower than that in the control cells (P<0.05), and the expression in the cells treated with the agent for different time lengths was also significantly lower than that in the control cells (P<0.01).</p><p><b>CONCLUSION</b>Simvastatin can reduce CX3CR1 expression in the monocytes of the patients with acute coronary syndrome in a concentration- and time-dependent manner, so as to reduce the inflammation and stabilize the vascular plaques.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Blood
/
Monocytes
/
Gene Expression
/
Simvastatin
/
Receptors, Chemokine
/
Reverse Transcriptase Polymerase Chain Reaction
/
Therapeutic Uses
/
Drug Therapy
/
Acute Coronary Syndrome
/
CX3C Chemokine Receptor 1
Limits:
Female
/
Humans
/
Male
Language:
Chinese
Journal:
Journal of Southern Medical University
Year:
2008
Type:
Article
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