Expression of human telomerase reverse transcriptase in renal cell carcinoma and its clinical significance / 南方医科大学学报
Journal of Southern Medical University
;
(12): 272-274, 2008.
Article
in Chinese
| WPRIM
| ID: wpr-293398
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the expression of human telomerase reverse transcriptase (hTERT) in renal cell carcinoma (RCC) and its clinical significance.</p><p><b>METHODS</b>The expression levels of hTERT mRNA and protein were detected using RT-RCR and Western blotting in 45 RCC tissues, 45 adjacent tissues and 786-0 cell line, and the associations of hTERT expression with the tumor size, clinical stage, pathological type and grade were evaluated.</p><p><b>RESULTS</b>hTERT mRNA and protein was expressed at significantly higher levels in RCC tissues than in the adjacent tissues (P=0.000), and no correlation of hTERT expression was found with the tumor size, clinical stage, pathological type or grade.</p><p><b>CONCLUSION</b>hTERT might serve as a diagnostic and prognostic marker for RCC, and also shed light on the new clues for gene therapy of RCC.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
RNA, Messenger
/
Carcinoma, Renal Cell
/
Biomarkers, Tumor
/
Telomerase
/
Genetics
/
Metabolism
Limits:
Adult
/
Aged
/
Female
/
Humans
/
Male
Language:
Chinese
Journal:
Journal of Southern Medical University
Year:
2008
Type:
Article
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