Combined assay of soluble CD30 and hepatocyte growth factor for diagnosis of acute renal allograft rejection / 南方医科大学学报
Journal of Southern Medical University
;
(12): 241-242, 2008.
Article
in Chinese
| WPRIM
| ID: wpr-293407
ABSTRACT
<p><b>OBJECTIVE</b>To study the value of detection of both preoperative soluble CD30 (sCD30) and hepatocyte growth factor (HGF) level 5 days after transplantation in the diagnosis of acute rejection of renal allograft.</p><p><b>METHODS</b>Preoperative serum sCD30 levels and HGF level 5 days after transplantation were determined in 65 renal-transplant recipients using enzyme-linked immunosorbent assay. The recipients were divided according to the sCD30 levels positivity. Receiver operating characteristic (ROC) curves were used to assess the value of HGF level on day 5 posttransplantation for diagnosis of acute renal allograft rejection, and the value of combined assay of the sCD30 and HGF levels was also estimated.</p><p><b>RESULTS</b>After transplantation, 26 recipients developed graft rejection and 39 had uneventful recovery without rejection. With the cut-off value of sCD30 of 120 U/ml, the positivity rate of sCD30 was significantly higher in recipients with graft rejection than in those without (61.5% vs 17.9%, P<0.05). Recipients with acute rejection showed also significantly higher HGF levels on day 5 posttransplantation than those without rejection (P<0.05). ROC curve analysis indicated that HGF levels on day 5 posttransplantation was a good marker for diagnosis of acute renal allograft rejection, and at the cut-off value of 90 ug/L, the diagnostic sensitivity was 84.6% and specificity 76.9%. Evaluation of both the sCD30 and HGF levels significantly enhanced the diagnostic accuracy of acute graft rejection.</p><p><b>CONCLUSION</b>Combined assay of serum sCD30 and HGF levels offers a useful means for diagnosis of acute renal allograft rejection.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Transplantation, Homologous
/
Blood
/
Enzyme-Linked Immunosorbent Assay
/
ROC Curve
/
Sensitivity and Specificity
/
Kidney Transplantation
/
Hepatocyte Growth Factor
/
Ki-1 Antigen
/
Diagnosis
/
Graft Rejection
Type of study:
Diagnostic study
/
Prognostic study
Limits:
Humans
Language:
Chinese
Journal:
Journal of Southern Medical University
Year:
2008
Type:
Article
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